John Jonas recommends that you Mozy to safety. Mozy is an online backup service and tool. You get 2Gb free is you are willing to read a newsletter once a week. Even the 5 and 10Gb service is pretty cheap. Unfortunately the only client is for Windows, but they're "working hard on developing a Mozy client for other platforms." Uh-huh.
My back up solution works like this. I always buy another of whatever sized harddrive is in my laptop (120Gb at the moment), put it in a firewire enclosure and backup using Synchronize Pro. I make a bootable image. If my laptop were damaged, stolen, etc. I can grab the bootable 2.5 inch drive and firewire boot from any other Mac. Works like a charm--I've used it. The only thing I don't get is offsite backup. If I were really paranoid, I'd buy two and keep one at the office and one at home.